Cialis Side Effects

Remote Pharmacy Research Team
May 29, 2025

Cialis, the brand name for tadalafil, is widely prescribed to treat erectile dysfunction and benign prostatic hyperplasia. It is known for its long-lasting effect and flexibility in dosing, which makes it a popular option among men looking for a reliable ED treatment. However, like any prescription medication, it can cause side effects, ranging from mild discomfort to reactions that may need medical attention.

Understanding the possible side effects of Cialis before starting treatment helps set realistic expectations and ensures safer use. This guide provides a clear overview of the most common and serious reactions associated with tadalafil, including what to watch for and when to talk to your doctor.

Overview of Cialis (Tadalafil) and its Approved Uses

Cialis is a prescription medication that contains tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor. It works by improving blood flow through the blood vessels, especially in areas involved in sexual function and urinary control.

Cialis is approved by regulatory agencies for three main conditions:

Erectile Dysfunction (ED): Cialis helps men achieve and maintain an erection when sexually aroused. It improves the body's natural response to stimulation without creating an automatic or constant erection.

Benign Prostatic Hyperplasia (BPH): Men with BPH experience urinary symptoms like difficulty urinating, frequent urination, or weak flow. Cialis helps relax the muscles in the bladder and prostate, improving urine flow and reducing discomfort.

ED with BPH Combined Treatment: For men who experience both conditions, Cialis is approved as a dual-therapy solution. It treats both erectile issues and urinary symptoms with a single daily dose.

In some cases, tadalafil is also used under other brand names for conditions like pulmonary arterial hypertension, but these uses are handled under different dosage guidelines and should not be confused with Cialis.

Common Side Effects of Cialis

Cialis is well tolerated by most patients, but like any medication, it can cause side effects. These effects are usually mild and temporary, especially when the medication is taken as prescribed. Most common side effects occur due to the way tadalafil relaxes blood vessels and affects smooth muscle.

Some of the most frequently reported side effects include:

  • Headache
  • Indigestion or stomach discomfort
  • Back pain
  • Muscle aches, especially in the arms or legs
  • Facial flushing (a warm, red feeling in the face or neck)
  • Nasal congestion
  • Dizziness or a lightheaded feeling, especially when standing up quickly

These effects often appear within the first few hours after taking the medication and tend to decrease with regular use or as the body adjusts. Back and muscle pain may appear 12 to 24 hours after use and typically resolve within 48 hours.

While these side effects are not dangerous for most users, it’s important to monitor how your body reacts. If any symptom becomes persistent or interferes with daily life, a doctor should be consulted to adjust the dose or explore alternatives.

Serious Side Effects to Watch For

While Cialis is generally safe when taken as directed, there are potential serious side effects that require immediate medical attention. These reactions are less common but may indicate underlying health issues or dangerous responses to the medication.

The most serious side effects include:

  • Chest pain or pressure, which may signal heart-related complications
  • Shortness of breath or difficulty breathing
  • Sudden vision loss in one or both eyes
  • Sudden hearing loss or ringing in the ears
  • Painful or prolonged erection lasting more than 4 hours (priapism)
  • Severe dizziness or fainting

These symptoms could be signs of cardiovascular strain, nerve complications, or vascular problems. If any of these occur, it is essential to stop taking Cialis and seek emergency care immediately.

Rare but Severe Cialis Reactions

In rare cases, Cialis may trigger severe reactions that are not always linked to dosage or known risk factors. These events are uncommon but must be taken seriously when they occur.

  • Potential severe reactions include:
  • Allergic reactions, such as swelling of the lips, face, or throat, which can cause difficulty breathing
  • Severe skin reactions, like peeling, blistering, or widespread rash
  • Liver problems, which may appear as yellowing of the skin or eyes (jaundice), dark urine, or persistent fatigue
  • Kidney issues, especially in patients with pre-existing renal impairment

Although these effects are rare, reporting them early can prevent complications. Patients with a history of liver or kidney disease should discuss their condition with a doctor before starting Cialis. Any new or worsening symptoms should always be communicated to a healthcare provider.

Factors that can Influence Side Effects

Not everyone experiences side effects from Cialis in the same way. Several factors can influence how your body reacts to tadalafil. Understanding these variables helps reduce risks and supports a safer treatment experience.

Dosage Levels: 5 mg vs. 20 mg

The strength of the dose has a direct impact on how side effects appear. Lower doses like 5 mg, often used for daily treatment, tend to cause fewer and milder side effects. Higher doses, such as 10 mg or 20 mg, are used as needed and may result in stronger reactions, especially in men who are new to the medication.

Starting at the lowest effective dose and adjusting only under medical guidance is the best way to minimize side effects while achieving results.

Interactions with Alcohol and Other Medications

Combining Cialis with alcohol may increase the chances of dizziness, low blood pressure, or fainting. Excessive alcohol use can also reduce the medication’s effectiveness.

Other medications — including nitrates, alpha-blockers, antifungals, HIV drugs, and blood pressure treatments — may interact negatively with tadalafil. These combinations can increase side effect risk or cause serious drops in blood pressure.

Always disclose all current medications to your doctor before starting Cialis.

Underlying Health Conditions

Certain medical conditions can affect how well your body tolerates tadalafil. For example, patients with heart disease, low blood pressure, liver problems, or kidney impairment may be more sensitive to the effects of the drug.

In some cases, Cialis may not be recommended at all due to the risk of serious side effects. A medical review helps ensure that the treatment is safe and appropriate for your individual health status.

How to manage and minimize Side Effects

Most Cialis side effects are mild and can be reduced with small adjustments to how the medication is used. Taking a proactive approach helps improve your comfort and treatment experience.

To manage side effects:

  • Take Cialis with or after food to ease stomach-related symptoms like indigestion or nausea.
  • Stay hydrated and avoid alcohol to reduce the risk of dizziness or headaches.
  • Start with the lowest effective dose and increase only if needed under medical supervision.
  • Avoid combining with conflicting medications, especially nitrates and blood pressure drugs.
  • Monitor how your body responds, especially during the first few doses. If any symptom becomes persistent, speak with your doctor immediately.

Side effects tend to fade over time for many users. If they continue or worsen, a dosage adjustment or medication change may be necessary.

Cialis Side Effects Compared to Other ED Medications

Cialis (tadalafil) has a similar safety profile to other PDE5 inhibitors like sildenafil (Viagra), vardenafil (Levitra), and avanafil (Stendra). However, its longer duration of action means some side effects — such as muscle aches or back pain — may last longer.

Here’s how Cialis compares:

  • Headaches and flushing are common across all ED medications.
  • Visual disturbances are more often reported with sildenafil.
  • Muscle pain and back discomfort occur more frequently with tadalafil than with other options.
  • Cialis daily dosing may lead to more stable side effect patterns, while as-needed use can lead to more noticeable peaks.

Choosing the right ED medication depends not only on how well it works but also on how well it's tolerated. A consultation with a doctor can help identify which option provides the best balance between effectiveness and comfort.

Start your ED treatment with Remote Pharmacy today

Getting help for erectile dysfunction no longer requires in-person visits or long waits. With Remote Pharmacy, you can access expert care, trusted medications like Cialis and Sildenafil, and discreet delivery — all from the comfort of your home.

We are committed to offering safe, evidence-based treatment with ongoing support. Whether you're just starting or looking to switch medications, our platform makes the experience smooth, safe, and personalized to your needs.

Take the first step toward better sexual health, and start your ED treatment with Remote Pharmacy today.

Subscribe to our newsletter
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.